Publicaciones | Departamento de Bioquímica y Biología Molecular I

Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes.

Alkylphospholipids: An update on molecular mechanisms and clinical relevance

The cis-acting replication element of the Hepatitis C virus genome recruits host factors that influence viral replication and translation

Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)

Cholesterol homeostasis and autophagic flux in perifosine-treated human hepatoblastoma HepG2 and glioblastoma U-87 MG cell lines

New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1

Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives.

Choline kinase active site provides features for designing versatile inhibitors

New Non-symmetrical Choline Kinase Inhibitors

Alkylphospholipids deregulate cholesterol metabolism and induce cell cycle arrest and autophagy in U-87MG cells

Lipid efflux mediated by alkylphospholipids in HepG2

Interference of antitumoral alkylphospholipids with membrane lipid metabolism in hepatoma HepG2 cells

Design, synthesis, theoretical calculations and biological evaluation of new nonsymmetrical choline kinase inhibitors

Antitumoral alkylphospholipids induce cholesterol efflux from the plasma membrane in HepG2 cells

Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues

Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids

Hexadecylphosphocholine alters nonvesicular cholesterol traffic from the plasma membrane to the endoplasmic reticulum and inhibits the synthesis of sphingomyelin in HepG2 cells

Hexadecylphosphocholine interferes with the intracellular transport of cholesterol in HepG2 cells

Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells

Effects of ethanol on the retailoring of neutral lipids and phospholipids in brain mitochondria and microsomes

Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells

Ethanol specifically alters the synthesis, acylation and transbilayer movement of aminophospholipids in rat-liver microsomes

CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury.

Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells.

Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity

Hexadecylphosphocholine inhibits phosphatidylcholine synthesis via both the methylation of phosphatidylethanolamine and CDP-choline pathways in HepG2 cells

Resistance of HepG2 cells against the adverse effects of ethanol related to neutral lipid and phospholipid metabolism

Comparative study of the effects of short- and long-term ethanol treatment and alcohol withdrawal on phospholipid biosynthesis in rat hepatocytes

Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells

Modulation of biosynthesis of phosphatidylcholine via CDP-choline in rat liver. Influence of ethanol on the microsomal cholinephosphotransferase

Chronic ingestion of ethanol stimulates lipogenic response in rat hepatocytes